Figure 5
From: Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains
Schematic representation of identifying and analyzing the crosstalk of dysfunctional pathways in six AD brain regions. (a) Gene sets of AD pathway and its neighbor pathways are identified from KEGG; (b) Networking the proteins by the integrated PPI from five known databases and mapping the region specific gene expression profiling information to the network of pathways; (c) Identifying the relationships among AD related pathways in six brain region and clustering them into groups respectively; (d) Ranking these pathways by dysfunctional score.