Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

Liu, Zhi-Ping; Wang, Yong; Zhang, Xiang-Sun; Chen, Luonan

doi:10.1186/1752-0509-4-S2-S11

BMC Systems Biology

Table 2 Rank of AD related pathways

From: Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

Region	Pathway ID	Size	Edge	Node	P-value	Description
EC	hsa04210	89	156	72	0.000001	Apoptosis
	hsa04060	279	259	220	0.000002	Cytokine-cytokine receptor interaction
	hsa04620	102	110	69	0.000695	Toll-like receptor signaling pathway
	hsa05220	75	181	69	0.003802	Chronic myeloid leukemia
	hsa05120	68	54	40	0.003899	Epithelial cell signaling in Helicobacter pylori infection
HIP	hsa04310	152	152	83	0.000000	Wnt signaling pathway
	hsa05214	65	113	52	0.000000	Glioma
	hsa04060	279	259	220	0.000001	Cytokine-cytokine receptor interaction
	hsa04012	87	200	71	0.000002	ErbB signaling pathway
	hsa05215	90	181	72	0.000002	Prostate cancer
MTG	hsa04330	46	59	34	0.000000	Notch signaling pathway
	hsa05120	68	54	40	0.000000	Epithelial cell signaling in Helicobacter pylori infection
	hsa04310	152	152	83	0.000003	Wnt signaling pathway
	hsa04520	78	105	59	0.000024	Adherens junction
	hsa04210	89	156	72	0.000388	Apoptosis
PC	hsa04060	279	259	220	0.000000	Cytokine-cytokine receptor interaction
	hsa04640	87	49	62	0.000000	Hematopoietic cell lineage
	hsa04115	69	72	46	0.000049	p53 signaling pathway
	hsa04210	89	156	72	0.000689	Apoptosis
	hsa05217	55	33	26	0.001264	Basal cell carcinoma
SFG	hsa04330	46	59	34	0.000000	Notch signaling pathway
	hsa04510	203	340	150	0.000000	Focal adhesion
	hsa04920	67	79	39	0.000002	Adipocytokine signaling pathway
	hsa04210	89	156	72	0.000009	Apoptosis
	hsa05120	68	54	40	0.000190	Epithelial cell signaling in Helicobacter pylori infection
VCX	hsa04060	279	259	220	0.000000	Cytokine-cytokine receptor interaction
	hsa04640	87	49	62	0.000000	Hematopoietic cell lineage
	hsa04340	57	14	11	0.000121	Hedgehog signaling pathway
	hsa04510	203	340	150	0.000279	Focal adhesion
	hsa04662	65	93	51	0.002533	B cell receptor signaling pathway

The most significant 5 pathways in six AD brain regions are ranked individually by “P-value”, which gives the p-value of dysregulation of the pathways. “Size” presents the number of genes contained in KEGG gene sets. “Edge” and “Node” represent the number of edges and nodes of these pathways.

Back to article page

ISSN: 1752-0509

Contact us

General enquiries: ORSupport@springernature.com