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Table 2 Rank of AD related pathways

From: Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

Region Pathway ID Size Edge Node P-value Description
EC hsa04210 89 156 72 0.000001 Apoptosis
  hsa04060 279 259 220 0.000002 Cytokine-cytokine receptor interaction
  hsa04620 102 110 69 0.000695 Toll-like receptor signaling pathway
  hsa05220 75 181 69 0.003802 Chronic myeloid leukemia
  hsa05120 68 54 40 0.003899 Epithelial cell signaling in Helicobacter pylori infection
HIP hsa04310 152 152 83 0.000000 Wnt signaling pathway
  hsa05214 65 113 52 0.000000 Glioma
  hsa04060 279 259 220 0.000001 Cytokine-cytokine receptor interaction
  hsa04012 87 200 71 0.000002 ErbB signaling pathway
  hsa05215 90 181 72 0.000002 Prostate cancer
MTG hsa04330 46 59 34 0.000000 Notch signaling pathway
  hsa05120 68 54 40 0.000000 Epithelial cell signaling in Helicobacter pylori infection
  hsa04310 152 152 83 0.000003 Wnt signaling pathway
  hsa04520 78 105 59 0.000024 Adherens junction
  hsa04210 89 156 72 0.000388 Apoptosis
PC hsa04060 279 259 220 0.000000 Cytokine-cytokine receptor interaction
  hsa04640 87 49 62 0.000000 Hematopoietic cell lineage
  hsa04115 69 72 46 0.000049 p53 signaling pathway
  hsa04210 89 156 72 0.000689 Apoptosis
  hsa05217 55 33 26 0.001264 Basal cell carcinoma
SFG hsa04330 46 59 34 0.000000 Notch signaling pathway
  hsa04510 203 340 150 0.000000 Focal adhesion
  hsa04920 67 79 39 0.000002 Adipocytokine signaling pathway
  hsa04210 89 156 72 0.000009 Apoptosis
  hsa05120 68 54 40 0.000190 Epithelial cell signaling in Helicobacter pylori infection
VCX hsa04060 279 259 220 0.000000 Cytokine-cytokine receptor interaction
  hsa04640 87 49 62 0.000000 Hematopoietic cell lineage
  hsa04340 57 14 11 0.000121 Hedgehog signaling pathway
  hsa04510 203 340 150 0.000279 Focal adhesion
  hsa04662 65 93 51 0.002533 B cell receptor signaling pathway
  1. The most significant 5 pathways in six AD brain regions are ranked individually by “P-value”, which gives the p-value of dysregulation of the pathways. “Size” presents the number of genes contained in KEGG gene sets. “Edge” and “Node” represent the number of edges and nodes of these pathways.