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Figure 1 | BMC Systems Biology

Figure 1

From: Discovering conditional co-regulated protein complexes by integrating diverse data sources

Figure 1

Schematic overview of conditional co-regulated protein complex identification. Given a condition, the active TFs are identified first and find out all target genes from TR data for each active TF and their protein products. The proteins and protein-protein interaction form a sub-network in the global PPI network. This sub-network will be decomposed into several weakly connected components (WCCs). A greedy searching way would be implemented to find out possible candidate groups, which is a linked sub-network in the WCC. We calculate a coherent score for candidates. The higher the score is, the more likely the candidate is to become a co-regulated complex. Finally, a relationship between the activity of TF and coherence of candidates with the conditions’ changing is investigated, which can be used to judge TF impact on their products’ function. Candidates with high coherent scores and their nodes exceeding a threshold are used as seeds to search additional extra members and predict new TRs.

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