From: Discovering conditional co-regulated protein complexes by integrating diverse data sources
Input: | L initial , T start , T end , N |
Output: | L rs |
step1: | L rs = L initial , calculates Score (L rs ) |
step2: | for i = 1 to N |
step2.1: | Calculates |
step2.2: | L try = L rs |
step2.3 | randomly choose a vertex v from L try , and choose a random arch e from E PPI , one of whose vertex is v. |
step2.4: | if (e ∊ L try ) if(L try is still connected without e and e ∉ Lin itial )delete e from L try else add e into L try |
step2.5: | Calculates Score(L try ) |
step2.6: | Δ = Score (L try ) − Score (L rs ) |
step2.7: | If(Δ > 0) L rs = L try else L rs = L try with the probability |
step3: | end |