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Table 1 Pseudo codes of our search method

From: Discovering conditional co-regulated protein complexes by integrating diverse data sources

Input:

L initial , T start , T end , N

Output:

L rs

step1:

L rs = L initial , calculates Score (L rs )

step2:

for i = 1 to N

step2.1:

Calculates

step2.2:

L try = L rs

step2.3

randomly choose a vertex v from L try , and choose a random arch e from E PPI , one of whose vertex is v.

step2.4:

if (e ∊ L try )

if(L try is still connected without e and e ∉ Lin itial )delete e from L try

else

add e into L try

step2.5:

Calculates Score(L try )

step2.6:

Δ = Score (L try ) − Score (L rs )

step2.7:

If(Δ > 0)

L rs = L try

else

L rs = L try with the probability

step3:

end