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Table 2 Results of BLM and NetLapRLS based on cross validation experiments 5 times

From: Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces

Data

Methods

AUC

AUPR

Sensitivity(%)

Specificity(%)

PPV(%)

* Enzyme

BLM

96.8(0.1)

85.2(0.2)

83.2(0.2)

99.82(0.002)

82.3(0.2)

 

NetLapRLS

95.6(0.3)

82.6(0.6)

81.0(0.5)

99.80(0.005)

80.2(0.5)

* Ion channel

BLM

97.2(0.1)

83.2(0.4)

28.0(0.03)

99.96(0.001)

96.4(0.1)

 

NetLapRLS

94.7(0.3)

82.5(0.5)

28.4(0.14)

99.98(0.005)

98.1(0.5)

* GPCR

BLM

94.4(0.3)

65.0(1.6)

28.0(0.8)

99.83(0.02)

83.9(2.4)

 

NetLapRLS

93.1(0.3)

66.0(1.5)

29.2(0.8)

99.87(0.03)

87.5(2.4)

Nuclear Receptor

BLM

84.1(0.9)

58.4(2.2)

14.0(0.6)

99.89(0.04)

90.0(3.9)

 

NetLapRLS

85.6(1.8)

51.6(2.3)

15.1(1.0)

99.97(0.07)

97.1(6.1)

  1. The AUC and AUPR scores are normalized to 100. The cutoff for sensitivity, specificity and PPV is set to choose the top one percentile in the predictoin score as positive.