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Table 2 Results of BLM and NetLapRLS based on cross validation experiments 5 times

From: Semi-supervised drug-protein interaction prediction from heterogeneous biological spaces

Data Methods AUC AUPR Sensitivity(%) Specificity(%) PPV(%)
* Enzyme BLM 96.8(0.1) 85.2(0.2) 83.2(0.2) 99.82(0.002) 82.3(0.2)
  NetLapRLS 95.6(0.3) 82.6(0.6) 81.0(0.5) 99.80(0.005) 80.2(0.5)
* Ion channel BLM 97.2(0.1) 83.2(0.4) 28.0(0.03) 99.96(0.001) 96.4(0.1)
  NetLapRLS 94.7(0.3) 82.5(0.5) 28.4(0.14) 99.98(0.005) 98.1(0.5)
* GPCR BLM 94.4(0.3) 65.0(1.6) 28.0(0.8) 99.83(0.02) 83.9(2.4)
  NetLapRLS 93.1(0.3) 66.0(1.5) 29.2(0.8) 99.87(0.03) 87.5(2.4)
Nuclear Receptor BLM 84.1(0.9) 58.4(2.2) 14.0(0.6) 99.89(0.04) 90.0(3.9)
  NetLapRLS 85.6(1.8) 51.6(2.3) 15.1(1.0) 99.97(0.07) 97.1(6.1)
  1. The AUC and AUPR scores are normalized to 100. The cutoff for sensitivity, specificity and PPV is set to choose the top one percentile in the predictoin score as positive.