A systems biology approach to identify effective cocktail drugs

BMC Systems Biology

Table 1 Prediction of drug combinations

Combination Drug	Score of Combination Drug	Scores of Individual Drugs	Prediction Results
Ros&Met	0.247611	(0.213158, 0.113546)	+
Ros&Chl	0.219065	(0.213158, 0.173858)	+
Ros&Tol	0.158606	(0.213158, 0.014646)	_
Ros&Phe	0.158969	(0.213158, 0.163439)	_
Tol&Chl	0.084770	(0.014646, 0.173868)	_
Tol&Phe	0.082675	(0.014646, 0.173868)	_
Tol&Met	0.084520	(0.014646, 0.163439)	_
Chl&Phe	0.161848	(0.173868, 0.163439)	_
Chl&Met	0.145706	(0.173868, 0.113546)	_
Phe&Met	0.117798	(0.163439, 0.113546)	_

Prediction of drug combinations, in which Ros, Tol, Chl, Phe and Met are the abbreviations of Rosiglitazone, Tolbutamide, Chlopropamide, Phenformin and Metformin respectively. + and _ denote effective combination and noneffective combination respectively. The scores listed in the table were obtained by setting λ to 0.5.

ISSN: 1752-0509