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Table 2 Type 2 Diabetes related genes affected

From: A systems biology approach to identify effective cocktail drugs

Gene symbol Corresponding protein name Ros&Met Met Ros
TCF4 Transcription factor 7-like 2 Yes No Yes
MAPK8IP1 C-jun-amino-terminal kinase-interacting protein 1 Yes No Yes
NEUROD1 Neurogenic differentiation factor 1 Yes No Yes
HNF4A Hepatocyte nuclear factor 4-alpha Yes No No
IRS1 Insulin receptor substrate 1 Yes No Yes
IRS2 Insulin receptor substrate 2 No Yes No
AKT2 RAC-beta serine/threonine-protein kinase No Yes No
AXL Protein AXL2 Yes No Yes
ERBB2 Receptor tyrosine-protein kinase erbB-2 Yes No Yes
PCSK2 Neuroendocrine convertase 2 Yes No Yes
RBP4 Retinol-binding protein 4 Yes No Yes
SLC8A1 Sodium/calcium exchanger 1 Yes No Yes
IKBKAP Elongator complex protein 1 Yes No No
SMARCA4 Probable global transcription activator SNF2L4 Yes Yes No
PMP22 Peripheral myelin protein 22 Yes Yes No
CSF1R Macrophage colony-stimulating factor 1 receptor Yes Yes Yes
RAG1 V(D)J recombination-activating protein 1 Yes Yes Yes
PLCE1 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 Yes Yes No
SHC1 SHC-transforming protein 1 No No Yes
  1. Type 2 Diabetes related genes affected by Ros&Met, Rosiglitazone and Metformin.