Figure 1

Association network inferred from integrated proteomic and transcriptomic data. The CLR method was used to infer association relationships between proteins on the basis of their abundance profiles (Z score > 6.0). The resulting network was extended by combining with association relationships inferred from transcriptomics data (Z score > 8.0). The network was visualized in Cytoscape. The nodes in the network are colored as follows: black, ribosomal proteins; red, SPI-2 proteins; yellow, SPI-1 proteins; orange, effectors which are secreted through SPI-2 T3SS but not in SPI-2; purple, regulators known to be essential for virulence; blue, targets identified in this study.