Schematic diagram showing the iterative workflow used to create the Cell Proliferation Network. The Cell Proliferation Network contains two components. The Literature Model (purple cylinder) was constructed from causal connections (within the tissue context and biological mechanism model boundaries) from the Selventa Knowledgebase. The content of the Literature Model was verified by performing Reverse Causal Reasoning (RCR) on four publicly available proliferation relevant data sets. In addition, the Literature Model was augmented with additional proliferation relevant RCR-derived nodes in this analysis, creating the Integrated Model. The Cell Proliferation Network (red cylinder) resulted from a comprehensive review of the Integrated Model.