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Table 1 Pathway Information for Building Crosstalk Model

From: Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles

Pathway Proteins Interactions
Epidermal Growth Factor (EGF) 49 66
Insulin-like Growth Factor Type 1 (IGF-1) 8 7
Tumor Necrosis Factor alpha (TNFα) 24 37
Insulin (INS) 50 65
Merge Four Pathways 102 150
Subgraph: all paths from receptors to c-Jun or c-Fos 55 89
Final network: remove with in degree = 0 46 77
  1. We combined four pathways from the Science Signaling Database (STKE). The first four rows of the table show the numbers of proteins and interactions in each pathway. The last three rows show the numbers of proteins and interactions as we merge and simplify the network.