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Table 1 Comparison of the areas with respect to different time ranges in Figure 8

From: An Integrated Mathematical Model of Thrombin-, Histamine-and VEGF-Mediated Signalling in Endothelial Permeability

MLC activation curve

Area under MLC activation curve with respect to different time range (time unit:min)

 

0-10

10-20

20-30

30-40

40-50

50-60

60-70

70-80

Curve 1:Histamine + Thrombin induced activation

5.9

7.8

7.6

6.9

6.1

5.2

4.7

4.0

Curve 2:Histamine-mediated activation

4.3

3.1

2.6

2.3

2.0

1.6

1.4

1.3

Curve 3:Thrombin-mediated activation

4.4

3.4

3.2

3.1

3.1

3.0

3.0

2.9

Simple sum of curve 2 and 3

8.7

6.5

5.8

5.4

5.0

4.7

4.5

4.3

Area difference between curve 1 and simple sum of curve 2 and 3

-2.8

1.3

1.8

1.5

1.1

0.6

0.2

-0.3

  1. Comparison of the areas under the thrombin and histamine induced MLC activation curve with those of thrombin-induced and histamine-induced MLC activation curves with respect to different time ranges in Figure 8.