Figure 2

Model of the adaptive immune system. The model of the adaptive immune system is comprised of four parts: 1) the generation of Teff and Treg cells from thymus; 2) T-cell activation by APCs; 3) the cross-regulation modeled by the Teff-Treg loop; and 4) T cell activation and memory populations in the tissue. The Teff-Treg loop is composed of a negative feedback between the two populations (Teff in red and Treg in blue). The model can be found in the additional files, and the parameters and initial conditions are listed in Table 1.