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Table 1 Similarity between modules identified by SSIM and four major prion subnetworks

From: An integrative approach to inferring biologically meaningful gene modules

Module Genes in the module PrPSc accumulation Microglial activation Neuronal cell death Synaptic degeneration
1 21 16 (76%) 5 (24%) 2 (10%) 0 (0%)
2 27 7 (26%) 21 (78%) 1 (4%) 1 (4%)
3 15 12 (80%) 0 (0%) 3 (20%) 0 (0%)
4 37 5 (14%) 5 (14%) 10 (27%) 20 (54%)
5 42 16 (38%) 14 (33%) 13 (31%) 4 (10%)
6 33 1 (3%) 1 (3%) 12 (36%) 24 (73%)
7 34 5 (15%) 22 (65%) 9 (26%) 2 (6%)
8 37 6 (16%) 0 (0%) 9 (24%) 24 (65%)
9 49 2 (4%) 7 (14%) 37 (76%) 6 (12%)
10 41 19 (46%) 19 (46%) 8 (20%) 2 (5%)
11 39 7 (18%) 29 (74%) 5 (13%) 4 (10%)
12 43 2 (5%) 13 (30%) 18 (42%) 12 (28%)
13 46 19 (41%) 38 (83%) 2 (4%) 0 (0%)
14 57 5 (9%) 36 (63%) 17 (30%) 7 (12%)
15 67 5 (7%) 2 (3%) 23 (34%) 49 (73%)
16 60 5 (8%) 0 (0%) 2 (3%) 54 (90%)
  1. For each module, the number and the proportion of genes corresponding to prion subnetworks are shown. Since some genes are involved in multiple subnetworks, the row-wise summation of proportions may exceed 100%.