Figure 2

Flux Variability Analysis (FVA). In panel (A) we depict the numerical participation of reactions with null variability along seven metabolic pathways included in the metabolic reconstruction. Reactions with null variability were defined as those whose upper and lower limit are equivalent. A fraction of reactions belonging to this classification are shown in (B). The set of reactions obtained by FVA are shown in (C). Here we have used the following abbreviations: PGM (phosphoglucomutase), FBA (fructose-bisphosphate aldolase), TPI (triose-phosphate isomerase), RPI (ribose-5-phosphate isomerase), PUNP1 (purine-nucleoside phosphorylase (Adenosine)), PUNP2 (purine-nucleoside phosphorylase (Deoxyadenosine)), PPCK(phosphoenolpyruvate carboxykinase), PHPB (acetoacetyl-CoA reductase), PHBS (PHB synthase), PGMT(phosphoglucomutase), PGI (glucose-6-phosphate isomerase), PDH (pyruvate dehydrogenase), PC (pyruvate carboxylase), NP1_r (nucleotide phosphatase), INSCR (inositol catabolic reactions (lumped)), INS2D (inositol 2-dehydrogenase), GUAPRTr (guanine phosphoribosyltransferase), GLGC (glucose-1-phosphate adenylyltransferase), GLCS1 (glycogen synthase (ADPGlc)), GAPD(glyceraldehyde-3-phosphate dehydrogenase), G6PDH2(glucose 6-phosphate dehydrogenase), FBP (fructose-bisphosphatase), ENO (enolase), EDD (6-phosphogluconate dehydratase), EDA (2-dehydro-3-deoxy-phosphogluconate aldolase), CS (citrate synthase), ACONTa (aconitase (half-reaction A, Citrate hydro-lyase)), ACONTb (aconitase (half-reaction B, Isocitrate hydro-lyase)), NIT (nitrogenase), NH3t (ammonia reversible transport), NH3e (Ammonium dissociation, extracellular), N2tr (Nitrogen exchange, diffusion) and MMSAD3 (methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde)).