Figure 1
From: Inferring causal genomic alterations in breast cancer using gene expression data
A framework for integrating wavelet based CNV inference and gene network analysis. The samples in a given gene expression study are first partitioned into two groups based on phenotypes such as poor versus good outcome, followed by differential expression analysis (t-test) to yields expression scores (ES t-statistics). Wavelet analysis is then performed on ES' ordered by gene chromosomal locations to detect significant consecutive regions (called inferred CNV regions). Using the same gene expression data, a gene regulatory network (Bayesian network) is constructed. Finally, the inferred CNV regions and the Bayesian network are input to the key driver analysis to identify potential cancer driver genes.