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Figure 3 | BMC Systems Biology

Figure 3

From: A retrosynthetic biology approach to metabolic pathway design for therapeutic production

Figure 3

Flowchart for ranking pathways. In order to rank pathways, each reaction r = 1 ... N in the enumerated pathways p1 ... p M is first tested for thermodynamical feasibility; enzyme candidates are subsequently tested for performance and homogeneity so that the one with the lowest cost is selected; the cost of toxicity of each reaction product is then added; finally, the nominal flux is estimated for the overall pathway.

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