Table 2 Native pathway identification in auxotrophic E. coli
From: A retrosynthetic biology approach to metabolic pathway design for therapeutic production
Compound | Total | Native pathways | % of natives in best 10 | p-value |
|---|---|---|---|---|
Alanine | 19 | 7 | 60.00% | 8.59e-08 |
Arginine | 1 | 1 | 100.00% | 4.65e-02 |
Asparagine | 3 | 3 | 100.00% | 8.42e-05 |
Aspartic acid | 7 | 7 | 100.00% | 6.91e-09 |
Cysteine | 11 | 5 | 100.00% | 1.32e-07 |
Glutamic acid | 74 | 53 | 100.00% | 6.41e-52 |
Glutamine | 7 | 5 | 100.00% | 1.41e-05 |
Glycine | 31 | 16 | 80.00% | 3.16e-08 |
Histidine | 4 | 4 | 100.00% | 4.85e-04 |
Isoleucine | 1 | 1 | 100.00% | 4.55e-02 |
Leucine | 1 | 1 | 100.00% | 4.54e-02 |
Lysine | 1 | 1 | 100.00% | 6.38e-02 |
Methionine | 107 | 106 | 100.00% | 1.08e-259 |
Phenylalanine | 4 | 1 | 100.00% | 6.38e-02 |
Proline | 1 | 1 | 100.00% | 2.17e-02 |
Serine | 2 | 2 | 100.00% | 1.11e-03 |
Threonine | 1 | 1 | 100.00% | 4.35e-02 |
Tryptophan | 2 | 2 | 100.00% | 1.89e-03 |
Tyrosine | 2 | 1 | 100.00% | 1.92e-02 |
Valine | 1 | 1 | 100.00% | 4.55e-02 |
Citrate | 4 | 3 | 100.00% | 5.71e-05 |
ATP | 12 | 6 | 100.00% | 6.73e-06 |
GTP | 2 | 2 | 100.00% | 2.08-03 |
ADP | 316 | 204 | 100.00% | 2.89e-169 |
GDP | 283 | 171 | 100.00% | < 1.0e-324 |