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Figure 2 | BMC Systems Biology

Figure 2

From: Decoding complex biological networks - tracing essential and modulatory parameters in complex and simplified models of the cell cycle

Figure 2

Cell cycle dynamics. Numerical simulation of the hybrid, DPL-model with the different linear systems indicated. During different parts of the cell cycle trajectory, different linear systems are used, here indicated on the time course of the variable y(t) = [MPF](t) with green, red, blue and magenta. These linear systems correspond to the four cell cycle phases G1, S/G2, M and EM, where EM is the ending of Mitosis. Mathematically, the linear system used at time t depends on [MPF](t) and t' (the time since the last occasion when [MPF] = θslp/steas detailed in [15]), and the linear systems are, green: [MPF] <θ25/weeand t' <τ (the system matrix A12 is used), red: [MPF] <θ25/weeand t' >τ (A11), blue: [MPF] >θ25/weeand t' <τ (A21), and magenta: [MPF] >θ25/weeand t' >τ (A22). The default parameter set of [15] was used in this figure.

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