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Table 2 Modulatory perturbation effects - comparison between the hybrid model predictions and the original model results

From: Decoding complex biological networks - tracing essential and modulatory parameters in complex and simplified models of the cell cycle

Modulatory Parameter Effects
Narrow Range Wide Range
Parameter Original Hybrid Parameter Original Hybrid
k 1 0.637 0.593 k 1 3.98 3.84
0.533 0.507 2.35 2.17
V i 25 0.523 0.25 1.77 2.35
V a 25 0.521 0.249 V i 25 1.27 0.764
0.361 0.502 V a 25 1.27 0.762
0.225 0.31 k 15 0.966 0. *
J i 25 0.222 0.29 0.965 0. *
0.168 0.106 0.948 0.0102
0.0367 0.0165 0.859 0.259
V iwee 0.0356 0.237 k 13 0.83 0. *
k 13 0.0352 0. * k 14 0.823 0. *
k 14 0.0345 0. * 0.801 1.08
V awee 0.0343 0.234 J i 25 0.786 1.01
k 11 0.0307 0. * 0.555 0.408
J 4 0.0259 0.0148 V iwee 0.304 0.65
0.0237 0.0148 V awee 0.303 0.649
0.0212 0. * k 9 0.207 0.396
k 9 0.0212 0.0191 k 11 0.202 0. *
0.02 1.64 × 10-7 J 4 0.157 0.0941
k 7 0.0181 0.000916 0.149 0.094
0.0142 0.000213 0.0817 0. *
0.0142 0.000237 0.065 0.00137
0.0135 0.00256 k 7 0.0491 0.00615
k 6 0.0118 0.000217 0.0421 0.000484
0.00821 0. * J awee 0.0392 0.097
J awee 0.00655 0.017 J a 25 0.0366 0.0435
k 4 0.00624 0.0134 k 4 0.0354 0.0632
J a 25 0.00574 0.00586 0.029 0. *
k 8 0.00574 0.000655 0.0238 0. *
k 10 0.00548 0.0189 k 10 0.022 0.396
J 5 0.00291 0.000132 k 8 0.0127 0.00918
k 15 0.00282 0. * 0.0102 3.04 × 10-7
0.00232 0. * J 5 0.00917 0.0000567
0.000926 0. * k 6 0.00828 0.000456
0.000595 0.00173 0.00567 0.0331
0.000429 5.63 × 10-9 J 15 0.00219 0. *
J 15 0.000331 0. * 0.00189 3.15 × 10-8
k 12 0.000263 0. * k 12 0.00144 0. *
J iwee 0.000166 0.00304 J 3 0.000874 0.000998
J 10 0.000166 0.0007 J 9 0.000724 0.00169
J 8 0.000166 0.000233 J iwee 0.000723 0.00895
J 3 0.000166 0.00016 J 10 0.000694 0.00437
J 16 0. 0. * J 8 0.000306 0.00149
k diss 0. 0. * J 16 0.000271 0. *
J 9 0. 0.00027 k diss 0.000207 0. *
J 7 0. 1.72 × 10-7 J 7 0.0000497 1.1 × 10-6
  1. Comparison between the sensitivity analysis of the original model and the analytical predictions of the hybrid model (mapped back to the original model parameters), at small range and wide range parameter perturbations. The sensitivity scores (original model) and (hybrid model), describing modulatory perturbation effects are used. The parameters are sorted by the sensitivity scores (based on the original model) in decreasing order; * indicates original model parameters without a counterpart in the hybrid model. Scores corresponding to modulatory effects (, ) are in bold.