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Figure 7 | BMC Systems Biology

Figure 7

From: A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis

Figure 7

Biochemical validation of differential effects of RSV, FF and T09 on inflammation. Quantification of transcription factor activity in liver homogenates and analysis of liver-derived inflammation markers in plasma. ApoE3Leiden mice treated with chow control diet T (for baseline levels) or an atherogenic high cholesterol diet (HC) in the presence or absence of rosuvastatin (RSV); fenofibrate (FF) and LXR agonist T0901317 (T09). A, p65-NFκB; B, C/EBPβ; C, p-STAT3 and circulating markers D, SAA; E, fibrinogen.

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BMC Systems Biology

ISSN: 1752-0509

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