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Figure 4 | BMC Systems Biology

Figure 4

From: Exploring pathway interactions in insulin resistant mouse liver

Figure 4

Two examples of overlap between pathways with respect to the algorithm for finding pathway interactions. Red nodes are proteins that are present in both pathways, dashed edges will be removed before finding shortest paths. A: A pathway pair with one overlapping protein (protein A) which connects to distinct paths within the two pathways. The overlap itself is not counted as interaction between the pathways, but by removing only the dashed edge A still acts as an indirect intermediate to establish a path between P1 and P2 via proteins B and E. B: A pathway pair which shares two proteins that do not connect to distinct paths within each pathway. In this case these proteins do not contribute to the pathway interaction, because the dashed edges are removed.

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