Figure 1

The Human Infectome Diseasome Newtok. a. The Human Infectome and Diseasome Network. Viral and host cellular proteins are respectively represented as red and blue nodes. Interactions between host cell proteins are represented by blue edges and define the Host Protein Interaction Network (HPIN). Interactions between viral and host proteins (red edges) are plugged onto the HPIN to define the Human Infectome Network (HIN). Host cell proteins directly interacting with viral proteins are named targeted proteins (TPs). Host cell proteins at a 1-hop distance of a targeted protein are named targeted proteins neighbours - (TP-Ns). Edges between human diseases (black nodes) and host cell proteins represent disease-gene associations as referred by OMIM. Proteins associated to OMIM diseases are termed disease-related proteins (DRPs). DRPs are either directly targeted by viruses (red stroke), or indirectly targeted by viruses (orange stroke). Network integration of HIN with the whole set of disease-gene associations defines the Human Infectome-Diseasome Network (HIDN). b. The virus-host interactome. The virus-host interactome part of HIN is represented as a multi-coloured graph (available in interactive format in Additional file 1). Blue nodes represent host cell proteins and viral proteins are colourized according to their taxonomy origin. Only the most connected viruses among the 110 viruses are represented in the legend: HPV - Human Papillomavirus; SV - Simian virus; HIV - Human Immunodeficiency Virus; HHV - Human Herpes Virus; HCV - Hepatitis C Virus; PTLV - Primate T-lymphotrophic Virus; HBV - Hepatitis B Virus. The size of nodes is proportional to the connectivity of proteins within the virus-host interactome. c. Distribution of viral protein and cellular protein connectivities in the Human Infectome Network. Probability density distributions P(k) of viral protein connectivity (k_h(VP)) and host protein connectivity values (k_h(TP)) are respectively given in red and blue and are linearized in log scale.