Skip to main content
Figure 2 | BMC Systems Biology

Figure 2

From: When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases

Figure 2

Topological properties of the Human Infectome Network . a. Topological properties of virus-targeted proteins. The average connectivity (top), centrality (middle) and bridging centrality (bottom) properties of targeted proteins (red bars) are compared to that of HPIN proteins not targeted by any virus (blue bars). Average measures are split into low connectivity proteins (LD - with a connectivity inferior or equal to 5, the median threshold) and high-connectivity proteins (HD - with connectivity superior to 5). Differences were statistically assessed using one-tailed Wilcoxon test; P-Values associated to the test are given (NS - Non significant testing P-Value > 0.05; P-Value < 0.05 *; P-Value < 0.01 **). b. The modular landscape of the Human Infectome Network. The deconvolution of HIN using the CFinder algorithm identified interconnected modules of proteins (nodes) and modules' linkers (available in an interactive format in Additional file 1). Protein modules and linkers are coloured according to the intensity of the viral attack. Highly targeted modules or linkers are red. Poorly targeted modules or linkers are black. Biological processes and molecular functions associated to highly targeted modules are pinpointed (one-tailed Exact Fisher test; Benjamini and Hochberg multiple testing correction; P-Value < 0.05 red arrows - P-Value < 0.15 grey arrows). c. Simulation of network robustness against preferential viral attack on central and bridging proteins. The figure represents the fragmentation of the entire human protein interaction network (HPIN) according to random or preferential attack according to network properties. The fragmentation is obtained by computing the relative size of the largest connected component (S) as a function of the percentage of removed nodes (f). Nodes removal is performed either randomly (black) or as a preferential attack mode where protein nodes are eliminated from the network in decreasing order of their connectivity (blue), centrality (red) and bridging (pink) values.

Back to article page