Figure 4

Results of the penicillin gene cluster and microbody quantifications. (A) Copy number of the penicillin gene cluster in the reference strain (Wisconsin 54-1255, 1 penicillin gene cluster, white bar) and in two prolonged chemostat runs of P. chrysogenum DS17690 at the penicillin production peak (t = 75 h, black bars) and the degenerated state (t = 500 h, grey bars). (B) Average number of microbodies per sub apical cell during chemostat cultivation: (filled circles) chemostat 5, (open squares) chemostat 6.