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Figure 8 | BMC Systems Biology

Figure 8

From: Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach

Figure 8

Levels of proteins and metabolites associated with PenG production, plotted against the specific penicillin production q P . Left panel: Relative protein amounts of the enzymes of the penicillin biosynthesis pathway (see Figure 1) compared to the reference condition at the penicillin production peak (first time point) in chemostat 1 (filled circles) and chemostat 4 (open diamonds). Middle panel: Intracellular levels of penicillin precursors and intermediates in chemostat 2 (open squares), chemostat 3 (filled triangles) and chemostat 4 (open diamonds). Right panel: Energy charge, calculated ratio of NADH/NAD from the Mannitol6P/F6P sensor reaction, intracellular PAA and the concentration ratio of PAA in chemostat 2 (open squares), chemostat 3 (filled triangles) and chemostat 4 (open diamonds).

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