Figure 1

Triplet motifs in epistatic interaction maps. A) Positive (green) and negative (red) epistatic interactions can be used to link genes A, B, and C in four combinations. B) Counts of each triplet type were measured (using the number of standard deviations (SD) from the means obtained using random graphs) for datasets where epistatic interactions were defined as the gene pairs with the upper- and lowermost 0.1, 0.5 and 1 percentile S-scores. The dashed line represents an SD enrichment of 2.0, and corresponds to a p-value of ~ 0.05, assuming normality. C) The table shows the number of observed and expected counts of triplet motifs for the E-MAP compendium. This table was calculated using the 1-percentile definition of epistasis and expected values are based on random graph analysis.