Figure 3

Functional enrichment among individual genes pairs in epistatic triplet motifs. A) Explanation of the scoring system. Edges in a triplet are arranged in order of increasing epistasis strength (i, ii, iii), with each position denoted '1' or '0' depending on whether the edge or adjoining nodes share a property. B) Odds ratios and associated p-values for protein complex membership, physical and genetic interactions, and shared biochemical pathway. C) Odds ratios and associated p-values for knockout phenotype, Gene Ontology Function, Process and Location, and presence of a paralog in S.cerevisiae (Additional File 3). In B and C, the dashed line indicates an odds ratio of one.