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Table 5 Results (CPU time in seconds) of the optimization of case O1- v4 for specific regions of k2 and k5 obtained with BARON for the SC model.

From: Steady-state global optimization of metabolic non-linear dynamic models through recasting into power-law canonical models

k5/k2

1

2

3

4

5

6

7

8

8

212.53

308.53

185.64

201.80

222.30

201.53

139.16

178.31

7

194.81

161.16

215.80

196.81

344.73

243.02

0.03

174.81

6

234.30

203.75

147.08

180.69

328.34

254.42

304.11

280.53

5

212.08

282.41

329.33

237.34

208.02

292.27

200.00

154.62

4

288.00

160.14

92.94

235.80

172.69

147.14

56.11

150.28

3

125.56

111.17

150.27

187.52

337.97

158.16

112.66

264.12

2

239.70

190.59

100.03

138.47

106.38

205.14

119.39

246.34

1

140.42

102.12

80.45

21.69

73.12

96.61

89.94

80.03

  1. Domain of each kr(4 ≤ k2 ≤ 5;0.2 ≤ k5 ≤ 0.8) has been split into 8 intervals with equal width.