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Table 1 Significantly modulated metabolites from the apolar fraction of TCDD-exposed HepG2 (P < 0.01)a.

From: Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Fatty acidb

Log2 ratio of TCDD/DMSOc

C12:0

-0.32

C14:0

-0.51

C14:1*

-0.51

C14:1*

-1.74

C16:1 (n-6)

-0.74

C16:1 (n-9)

-0.74

C17:0

0.26

C18:0

0.38

C18:1 (n-9)

-0.32

C18:1*

-0.51

C18:2*

-0.51

C18:2*

-0.74

C18:2*

0.38

C18:2*

-0.74

C18:2*

-0.74

C20:1

-0.32

C20:2*

-0.51

C20:2*

-0.51

C20:3*

-0.32

C20:3*

-0.74

C22:2

-0.74

C22:3

-0.51

Other

 

Triglycerides

-1.00

Cholesteryl ester

-0.51

  1. aadapted from Ruiz-Aracama et al. [42]
  2. bisomers, which cannot be distinguished from each other, are indicated by an asterisk (*)
  3. clog2 ratios between TCDD and vehicle control (DMSO).