Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Table 3 Cellular processes and pathway maps from MetaCore analyses.

Input data for MetaCore^a	Total number of maps	Cellular process (number of maps)^b
Transcripts	54	Amino acid metabolism (14)
		Carbohydrates metabolism (2)
		Lipid metabolism (11)
		Metabolism of mediators (6)
		Small GTPase mediated signal transduction (1)
		Steroid metabolism (9)
		Transcription (3)
		Vitamin and cofactor metabolism (5)
		Other (2)
Metabolites	58	Amino acid metabolism (21)
		Apoptosis (2)
		G-protein coupled receptor protein signaling (10)
		Immune response (1)
		Lipid metabolism (5)
		Nucleotide metabolism (3)
		Transcription (1)
		Vitamin and cofactor metabolism (4)
		Other (11)
Integrated data	73	Amino acid metabolism (21)
		Apoptosis (1)
		G-protein coupled receptor protein signaling (14)
		Immune response (2)
		Intracellular receptor-mediated signaling pathway (2)
		Lipid metabolism (7)
		Metabolism of mediators (3)
		Nucleotide metabolism (3)
		Small GTPase mediated signal transduction (1)
		Transcription (4)
		Vitamin and cofactor metabolism (4)
		Other (11)

^aThe significantly modulated genes, metabolites and integrated data of the TCDD-exposed HepG2 were used as input.
^bCellular processes with at least four maps are high-lighted in bold

ISSN: 1752-0509