Figure 7
From: Efficient characterization of high-dimensional parameter spaces for systems biology
Reaction diagram of the model of a simplified biochemical oscillator with two feedback loops proposed by Hafner et al.[51]. The protein R is produced at a constant rate k1 and its phosphorylated state R p is produced at a rate, k2. The phosphorylated protein Z p modulates this phosphorylation rate by means of a positive feedback loop (blue diagram in the figure). In addition, R p is degraded with a rate, k3 that depends on the phosphorylated protein Y p by means of a negative feedback loop (red diagram in the figure).