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Figure 10 | BMC Systems Biology

Figure 10

From: Computational modelling elucidates the mechanism of ciliary regulation in health and disease

Figure 10

The dynamics of current alterations in the absence of voltage clamp. The Ca2+ and K+ current dynamics were calculated in response to the membrane potential shift in the absence of voltage holding conditions (A-G). The membrane potential was depolarised from the normalised value V0 = -30 mV to -12.5 mV (A) and 25 mV (G), which represent the smallest and the largest change shift, respectively. The currents elicited by the membrane potential alteration within the range are shown in (B)-(F). I C a 2 + , I K + and I Full represent calcium, potassium and full currents, respectively. The comparison with the Ca2+ current responses to membrane potential shift obtained under the voltage clamped conditions (Figure 3, 5 and 9) reveals significant differences in the dynamics. (H) Voltage current characteristic is calculated using the current amplitudes from the currents dynamics for the full (I Full ) and Ca2+ ( I C a 2 + ) currents. The steady-state voltage current relationship is calculated according to the stationary current values, (I PS ).

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