Figure 10

The dynamics of current alterations in the absence of voltage clamp. The Ca²⁺ and K⁺ current dynamics were calculated in response to the membrane potential shift in the absence of voltage holding conditions (A-G). The membrane potential was depolarised from the normalised value V₀ = -30 mV to -12.5 mV (A) and 25 mV (G), which represent the smallest and the largest change shift, respectively. The currents elicited by the membrane potential alteration within the range are shown in (B)-(F). $I_{C{a}^{2+}}$, $I_{K^{+}}$ and I _Full represent calcium, potassium and full currents, respectively. The comparison with the Ca²⁺ current responses to membrane potential shift obtained under the voltage clamped conditions (Figure 3, 5 and 9) reveals significant differences in the dynamics. (H) Voltage current characteristic is calculated using the current amplitudes from the currents dynamics for the full (I _Full ) and Ca²⁺ ($I_{C{a}^{2+}}$) currents. The steady-state voltage current relationship is calculated according to the stationary current values, (I _PS ).