Static and dynamic intraciliary Ca2+ concentration levels under membrane potential fixed conditions. (A) The model predictions for the relationship between the membrane potential and intraciliary Ca2+ concentration. (B) The maximum amplitude of Ca2+ current generated in response to the transmembrane potential shift is shown as function of the applied shift. The model predictions are obtained by setting the parameter α to 2, 3, and 4 in equations 18-21. The parameter α reflects the steepness of Ca2+ current dependence on membrane voltage. The model-based analysis shown here unravels the bell-shaped dependence of intraciliary Ca2+ concentration on membrane potential and the inverse relationship between the Ca2+ current magnitudes and the degree of membrane depolarisation.