Figure 9
From: Computational modelling elucidates the mechanism of ciliary regulation in health and disease
Ca2+ concentration dynamics response to transmembrane potential shift in the presence of K+ current. (A) The intraciliary Ca2+ dynamics is computed in response to transmembrane potential shift by incorporating the contribution from K+ channels to the overall current. Comparison of these results with Figures 3 and 5 suggests that while K+ currents introduce some quantitative changes, the overall qualitative characteristics of the response remain the same. The non dimensional membrane potential values following voltage shift are indicated for each predicted response. (B) The amplitude of the generated Ca2+ concentration response is shown as a function of membrane potential alteration. The amplitude of the current is approximately linearly inversely proportional to the magnitude of the applied membrane potential shift.