TY - JOUR AU - Wu, Wu-Hsiung AU - Wang, Feng-Sheng AU - Chang, Maw-Shang PY - 2011 DA - 2011/09/19 TI - Multi-objective optimization of enzyme manipulations in metabolic networks considering resilience effects JO - BMC Systems Biology SP - 145 VL - 5 IS - 1 AB - Improving the synthesis rate of desired metabolites in metabolic systems is one of the main tasks in metabolic engineering. In the last decade, metabolic engineering approaches based on the mathematical optimization have been used extensively for the analysis and manipulation of metabolic networks. Experimental evidence shows that mutants reflect resilience phenomena against gene alterations. Although researchers have published many studies on the design of metabolic systems based on kinetic models and optimization strategies, almost no studies discuss the multi-objective optimization problem for enzyme manipulations in metabolic networks considering resilience phenomenon. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-5-145 DO - 10.1186/1752-0509-5-145 ID - Wu2011 ER -