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Figure 1 | BMC Systems Biology

Figure 1

From: TIGER: Toolbox for integrating genome-scale metabolic models, expression data, and transcriptional regulatory networks

Figure 1

TIGER platform overview. TIGER converts Boolean rules to MILPs. Rules are first simplified by substitution and converted into a system of linear inequalities. The rules are optionally attached to a COBRA model by coupling indicators of reaction participation (R i ) to the reaction flux v i . In addition to serving as a platform for developing new algorithms, TIGER models can be integrated with high-throughput expression data to generate context-specific models using variations on the GIMME, iMAT, and MADE algorithms.

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BMC Systems Biology

ISSN: 1752-0509

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