Figure 5From: TIGER: Toolbox for integrating genome-scale metabolic models, expression data, and transcriptional regulatory networksConceptual example using the enhanced MADE algorithm. Workflow for integrating expression data from evolved bacterial cultures using TIGER's enhanced MADE algorithm. Parent strain P splits into strains A and B. Strain A further diverges into strains A 1 and A 2. Expression data indicates fold change between different strains for each gene. The interaction matrix indicates that the first column of fold changes represents a change from P to A, the second column from P to B, etc. The expression data and the interaction matrix are combined to create gene states for each bacterial strain.Back to article page