Table 1 Kinetic parameters and metabolite concentrations used in a computational model of the E. coli thioredoxin system.

Metabolites

(μ M)

NADPH

137

[61]

NADP

1

-

TrxSH

1

[62]^a

TrxSS

1

[62]^a

PSS

4.23

b

PSH

1

-

MetSO

970

b

Met

4.83 × 10⁴

b

PAPS

0.07

[59]^{b, c}

SO₃^2-

1

-

PAP

1

-

H₂O₂

0.02

[27, 28]

H₂O

1

-

Thioredoxin

reductase

[TR]

4.74 μ M

[50]

k _cat

22.75 s^-1

[63]

K _nadph

1.2 μ M

[64]

K _trxss

2.8 μ M

[64]

PSS reduction

k ₂

0.064 μ M^-1s^-1

[10]

Methionine sulfoxide

reductase

[MsrA]

2.35 μ M

b

k _cat

3.7 s^-1

[12]

K _metso

1900 μ M

[12]

K _trxsh

10 μ M

[12]

PAPS reductase

[PR]

0.345 μ M

b

k _cat

3.5 s^-1

[14]

K _paps

22.5 μ M

[14]

K _trxsh

13.7 μ M

[14]

k _pr

0.156 μ M^-1s^-1

b

Tpx

[Tpx]

4.88 μ M

[57]

k _H2O2

44 μ M^-1.s^-1

[15]

k _trxsh

3000 μ M^-1.s^-1

[15]