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Table 3 The percentage of off-target effects decreased as the network size increased.

From: Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

n Off Target Effects
3 73.9
  vertical lateral
5 27.9 6.0
7 13.5 0.0
  1. The n = 3 network's restricted parameter space produced 73.9% off-target effects. The n = 5 and n = 7 vertical case networks produced 27.9% and 13.5% off-target effects, respectively, using the same parameter space. In the lateral case the drop was more dramatic with the n = 5 and n = 7 networks producing 6% and 0% off-target effects, respectively. Parameter values used in cycles 4, 5, 6 or 7 were homogenous with cycle 3. All percentages are out of 5000 randomly selected parameter sets using the parameter space depicted in Figure 3I.