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Table 4 Off-target effects can amplify downstream of cycle 2.

From: Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity

  Cycle 2 Cycle 4
Cycles 1-3 with restricted ranges and cycle 4 with default ranges
% Off Target Effects 75.3 35.5
% Off Target Effects with Amplification -- 23.4
% Off Target Effects without Amplification -- 12.1
Cycles 1- 4 with restricted ranges
% Off Target Effects 45.3 67.4
% Off Target Effects with Amplification -- 61.9
% Off Target Effects without Amplification -- 5.5
  1. To test for downstream propagation of off-target effects from cycle 2, the extended n = 3 network was used. If an off-target effect occurred in cycle 4 and the size of the response in cycle 4 exceeded the size of the response in cycle 2, then an off-target effect with amplification was reported for cycle 4. First, the n = 3 restricted parameter space was used for cycles 1 - 3 and the default parameter ranges from Table 1 were used for cycle 4 (Additional File 3 Figure S4H). Next, cycles 2 - 4 were further restricted to ranges which favor off-target effect propagation from cycle 2 to 4 (Additional File 3 Figure S4I). Values listed in the table are percentages out of 5000 randomly selected parameter sets.