Contour plots of the objective function with scatter plots of the parameters' estimates obtained by DE from noisy data ( s = 20%) in a Monte Carlo-based approach. The plots correspond to two representative pairs of correlated parameters in the observation scenarios: a) CO; b) AO; and c) TO. Note that one pair of correlated parameters in the TO observation scenario corresponds to the initial values of the Rab5 protein. The green dot represents the reference parameter value from Eqs. (11) and (12). The red dots are the parameters' estimates obtained by the DE method with the Monte Carlo-based approach.