Table 1 Optimized parameter values of the TK model along with the corresponding process they describe

1

k_{ATG int}

0.25

1/min

Rate of production of ATG

2

k_{MADG int}

90

1/min

Rate of production of MADG

3

k_DMAG

0.0122

1/min

Rate of production of DMAG

4

k_oxd

33.254

1/min

Rate of oxidation of DMA^III

5

k_oxm

0.2375

1/min

Rate of oxidation of MMA^III

6

k_iAs^III_int

320

1/min

Rate of production of iAs^III

7

k_MMA^III_int

1200

1/min

Rate of production of MMA^III

8

n₃

8

-

Hill coefficient of inhibition of MMA^III production

9

Kd₃

12.94

μM

Dissociation constant of inhibition of MMA^III

10

f_GSHm

0.992

-

Coefficient of inhibition of MADG hydrolysis

11

kg_in

704.96

1/min

Rate of GSH production increase

12

k_DMA^III_int

0.8472

1/min

Rate of production of DMA^III

13

f_GSHd

0.9988

-

Coefficient of inhibition of DMAG hydrolysis

14

Vmax_t2

1.237

pmol/min

Maximal rate of MADG efflux

15

Km_t2

19.47

μM

Half saturation constant of MADG efflux

16

km_in

512.27

1/min

Rate of upregulation of MRP

17

k_ss

4.26

1/min

Steady state rate of efflux of iAs^III

18

τ_e

10

min

Time constant of AQP9 inactivation

19

k₀

4.2

1/min

Initial rate of efflux of iAs^III

20

k_inf

1.613

1/min

Influx of iAs^III

21

k_MMAext

0.0006

1/min

Rate of efflux of MMA

22

f_m

0.2

-

Coefficient of efflux of MMA

23

Vmax_t1

0.35

pmol/min

Maximal rate of ATG efflux

24

Km_t1

2.3

μM

Half saturation constant of ATG efflux

25

k_DMAext

0.002

1/min

Rate of efflux of DMA

26

f_d

3

-

Coefficient of efflux of DMA

27

Vmax_m

50

pmol/min

Maximal rate of ATG methylation

28

Km_m

9.32

μM

Half saturation constant of ATG methylation

29

n₁

1.22

-

Hill coefficient of ATG methylation

30

Kd₁

0.315

μM

Dissociation constant of ATG methylation

31

K_im

1.53

μM

Inhibition constant of ATG methylation

32

K_id

1

μM

Inhibition constant of MADG methylation

33

Vmax_d

8

pmol/min

Maximal rate of MADG methylation

34

Km_d

0.034

μM

Half saturation constant of MADG methylation

35

n₂

1.83

-

Hill coefficient of MADG methylation

36

Kd₂

2.33

μM

Dissociation constant of MADG methylation

37

ka_in

1.64

1/min

Rate of AS3MT efficiency increase

38

f_A

50

-

Coefficient of MADG methylation inactivation

39

k_TR

0.99

1/min

Rate of TR signaling

40

k_TRinact

987.13

1/min

Rate of TR inactivation

41

TR_C

15

-

Constant of TR inactivation

42

N

1.75

-

Hill coefficient of TR inactivation

43

TR₀

9.27

1/min

Steady state value of TR activity