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Table 2 Comparison of selected parameter values between two hepatocyte-level TK modeling formulations

From: Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior

Kinetic Process

Human-Hepatocyte TK model

Rat-Hepatocyte TK model

NP - iAsIII

0.38

0.38

NM - 1st Reaction (1/min)

3.35

0.02

NM - 2nd Reaction (1/min)

147.06

0.17

Biotransformation - 1st MRS

0.0008

33.33

  1. The two formulations are developed based on data of arsenic uptake and biotransformation in human and rat hepatocytes (NP: Normalized AQP9 activity, NM: Normalized AS3MT activity, MRS: Methylation Reaction Substrate)