TY - JOUR AU - Genc, Seda AU - Kurnaz, Isil A. AU - Ozilgen, Mustafa PY - 2011 DA - 2011/10/13 TI - Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data JO - BMC Systems Biology SP - 162 VL - 5 IS - 1 AB - Neuro-glial interactions are important for normal functioning of the brain as well as brain energy metabolism. There are two major working models - in the classical view, both neurons and astrocytes can utilize glucose as the energy source through oxidative metabolism, whereas in the astrocyte-neuron lactate shuttle hypothesis (ANLSH) it is the astrocyte which can consume glucose through anaerobic glycolysis to pyruvate and then to lactate, and this lactate is secreted to the extracellular space to be taken up by the neuron for further oxidative degradation. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-5-162 DO - 10.1186/1752-0509-5-162 ID - Genc2011 ER -