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Figure 2 | BMC Systems Biology

Figure 2

From: Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase

Figure 2

Variability of non-target redox enzymes. (A) Changes in off-target expression levels for wild-type Jurkat cells relative to pLKO empty vector control cells. Genes with significantly altered mRNA levels are colored green. (B) Changes in off-target expression levels for Grx1 shRNA (blue, circles), Trx1 shRNA (red, diamonds) and G6PD shRNA (orange, triangles), relative to pLKO control. (C) Venn diagram of significant gene changes. Statistical significance for all plots based upon p < 0.05.

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BMC Systems Biology

ISSN: 1752-0509

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