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Table 6 Statistics of the pathway database comparison of core metabolic processes

From: Critical assessment of human metabolic pathway databases: a stepping stone for future integration

  Number of (percentage of union)
  Genes EC numbers Metabolites Reactions
union 1723 -55% 959 -32% 2805 -40% 3713 -47%
consensus 264 (15%) + 2% 180 (19%) + 1% 316 (11%) + 2% 144 (4%) + 1%
majority score 875 (51%) + 9% 508 (53%) + 3% 757 (27%) + 6% 674 (18%) + 4%
Database Unique per database (percentage of union)
BiGG 75 (4%) + 3% 63 (7%) + 4% 276 (10%) - 1% 621 (17%) - 1%
EHMN 186 (11%) + 8% 125 (13%) + 7% 910 (32%) + 7% 1129 (30%) + 4%
HumanCyc 70 (4%) -16% 62 (6%) -15% 243 (9%) - 7% 326 (9%) - 4%
KEGG 180 (10%) + 8% 45 (5%) + 4% 209 (7%) + 1% 274 (7%) + 2%
Reactome 19 (1%) - 3% 8 (1%) 0 80 (3%) - 6% 154 (4%) - 4%
Total 530 (31%) + 1% 303 (32%) 0 1718 (61%) - 6% 2504 (67%) - 3%
  1. Genes: Entrez Gene IDs, including genes encoding for a component of a protein complex as separate entities. EC numbers: only fully specified EC numbers. Metabolites: if two metabolites of one database both match the same metabolite in another database this is counted as one match. Reactions: reactions where not required to match on e-, H+ and/or H2O. Differences with the outcomes of the global comparison (Table 3) are indicated in percentages for each level of comparison.