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Table 2 Data sets analyzed by RCR for assessment and augmentation of the Cellular Stress Network model

From: A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

Data Set Hyperoxia HOCl OxPAPC Hypoxia
Data Set ID GSE495 GSE15457 GSE20060 GSE11341
PubMed ID N/A 19376150 20170901 18469115
Perturbation 100% O 2 1.4 mM hypochlorous acid 40 μg/ml oxidized phospholipid 1% O 2
Tissue/Cells Whole lung RAW 267.4 cell line Aortic endothelial cells Lung microvascular endothelial cells
In vivo/in vitro In vivo In vitro In vitro In vitro
Species Mouse Mouse Human Human
Timepoint 48 h 6 h 4 h 48 h
Control 0 h 6 h untreated 4 h untreated 0 h
Platform Affymetrix U74v2 Affymetrix 430_2 Affymetrix HGU133A Affymetrix HGU133A
# State Changes 1122 1618 185 639
Measured outcome(s) None Cell viability, RT-PCR, and Western blot analysis of Nrf2 and Nrf2 target genes qRT-PCR for HMOX1, GJA5 Hypoxia-induced marker genes; Scratch wound assay