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Table 1 Analysis of cell compartment enrichment in the BIOGRID database.

From: Removing bias against membrane proteins in interaction networks

GO ID GO Term Median p-value
Overrepresented categories:   
32991 macromolecular complex 4.96E-105
43234 protein complex 1.80E-78
44428 nuclear part 1.06E-66
5622 intracellular 2.74E-54
44424 intracellular part 3.72E-53
44422 organelle part 8.61E-51
44446 intracellular organelle part 8.61E-51
5634 nucleus 2.43E-52
43229 intracellular organelle 8.85E-48
43226 organelle 8.85E-48
31981 nuclear lumen 1.27E-53
44451 nucleoplasm part 5.98E-38
5654 nucleoplasm 1.75E-38
44464 cell part 3.54E-33
5623 cell 4.46E-33
43228 non-membrane-bounded organelle 1.67E-34
43232 intracellular non-membrane-bounded organelle 1.67E-34
43233 organelle lumen 1.02E-31
31974 membrane-enclosed lumen 1.02E-31
43231 intracellular membrane-bounded organelle 4.99E-31
43227 membrane-bounded organelle 4.99E-31
16591 DNA-directed RNA polymerase II, holoenzyme 4.98E-11
5694 chromosome 7.67E-15
30529 ribonucleoprotein complex 2.76E-12
5730 nucleolus 6.52E-13
502 proteasome complex 2.37E-06
44427 chromosomal part 1.61E-14
5856 cytoskeleton 3.25E-07
5679 chromatin remodeling complex 1.70E-09
123 histone acetyltransferase complex 5.87E-10
44430 cytoskeletal part 1.65E-05
22624 proteasome accessory complex 9.47E-04
5838 proteasome regulatory particle 9.47E-04
44452 nucleolar part 2.30E-08
5669 transcription factor TFIID complex 7.26E-03
5681 spliceosome 4.85E-04
119 mediator complex 3.91E-04
124 SAGA complex 1.04E-05
5667 transcription factor complex 3.06E-04
812 SWR1 complex 1.15E-03
44453 nuclear membrane part 6.00E-03
Underrepresented categories:
943 retrotransposon nucleocapsid 2.88E-05
31224 intrinsic to membrane 1.22E-05
44429 mitochondrial part 3.18E-04
5740 mitochondrial envelope 4.89E-03
16021 integral to membrane 7.67E-05
44425 membrane part 1.85E-03
5743 mitochondrial inner membrane 7.18E-03
5739 mitochondrion 6.34E-03
  1. The median p-values were calculated after sampling 10 random sets of 1000 interactions from BIOGRID. P-values are shown after Bonferroni's correction for multiple hypotheses.