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Table 2 Correlation between membrane interaction content and centrality-lethality rule for different PPI techniques.

From: Removing bias against membrane proteins in interaction networks

Technique Unique interactions Fraction of membrane interactions Kendall's tau Kendall's tau (p-value) Indess (5) Assortativity coefficient
Affinity Capture-MS 26350 0.14 0.277 9.46E-96 1.864 -0.071
Co-localization 351 0.18 0.181 4.14E-04 1.996 0.214
Co-purification 1217 0.28 0.127 1.07E-04 1.558 -0.227
Reconstituted Complex 1959 0.29 0.167 3.49E-11 2.069 -0.101
Two-hybrid (without Miller et al (2005)) 7040 0.29 0.141 9.11E-20 1.657 -0.107
Affinity Capture-Western 4953 0.30 0.188 3.92E-24 1.894 0.112
BIOGRID (all techniques) 94877 0.30 0.190 4.98E-70 1.312 -0.102
Affinity Capture-RNA 1187 0.31 0.119 5.07E-05 1.833 -0.857
Biochemical Activity 5355 0.31 -0.034 0.104 0.792 -0.460
Co-fractionation 574 0.58 0.044 0.274 0.833 -0.163
PF-PCA 2395 0.65 0.018 0.505 0.904 0.171
SU-2HY 1941 0.99 -0.004 0.928 1.187 -0.074
  1. Note: the table was sorted in ascending order according the column with the "fraction of membrane interactions".
  2. The Kendall's tau and Indess(5) are both inversely correlated to the content of membrane interactions, while the assortativity coefficient is not.