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Figure 5 | BMC Systems Biology

Figure 5

From: Complex receptor-ligand dynamics control the response of the VEGF system to protease injury

Figure 5

Impact of VEGFf on VEGF-Receptor binding differs when VEGFf interacts with VEGFR1 and NP-1. Simulation results for (A) Model 1 (VEGFf can bind to VEGFR1 and NP-1) and (B) Model 2 (VEGFf cannot bind to VEGFR1 and NP-1) 3 h after introduction of VEGF(1 ng/ml or 0.023 nM) and VEGFf to the cell system. VEGF bound to VEGFR1 (open), VEGFR2 (filled), and sum of VEGF bound to VEGFR1, VEGFR2, NRP, and ECM (solid line)

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